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Elsevier

Libros en Toxicología

  • In Vitro Toxicity Indicators

    • 1 Edición
    • Volumen 1B
    • Charles A. Tyson
    • Inglés
    About the Series:In the tradition of Methods in Enzymology and Methods in Neurosciences, Academic Press is pleased to announce a new serial: Methods in Toxicology. There is a pressing need among researchers involved in toxicologic investigation for a series of publications that organizes and presents information on the latest experimental methodologies. To address the needs of researchers in toxicology, toxicologic pathology, pharmacology, and clinical biochemistry, this new serial provides comprehensive descriptions of state-of-the-art methods for evaluating drug and chemical toxicity. Thematic volumes focus on mechanistic approaches to the study of toxicity both in vitro and in vivo, taking advantage of the recent advances in the biological and chemical sciences that allow closer scrutiny of the mechanisms by which agents cause damage. Each volume begins with an introductory chapter that offers a broad guide to the application of methods addressed in that volume. Subsequent chapters contain detailed descriptions of research protocols, accessible both to experts and those new to toxicologic investigation. Included in each chapter are clearly defined procedures, discussions of limitations of the method, comparative considerations (species, sex, strain), interpretations of results, and explanations of how the methods may serve as alternatives to in vivo testing. Each volume of Methods in Toxicology is available in case binding for the library and Wire-O-binding for the laboratory. About the Book:Concurrent with the development of biological systems for in vitro toxicologic investigations (Volume 1A-In Vitro Biological Systems), techniques have evolved to detect and evaluate the diverse effects produced when toxicants interact with these systems. This volume describes methods for detecting and quantifying pertubations in various cellular parameters related to cell dysfunction and death (including apoptosis) associated with adverse toxicant action. Each endpoint measurement probes one aspect of the response of the biological system to a toxicant. When several techniques are used in combination, it is possible to derive a more complete understanding of the mechanism of toxicity at the cellular, tissue, or organ level. The methods collected here are organized by major categories of toxic effects, such as membrane damage, disruption of energy metabolism, and lipid peroxidation, commonly monitored by toxicologists during a comprehensive toxicity study. Specialized techniques of interest and value in mechanistic investigations are included. As with the first volume, the goal is not to obtain an exhaustive collection of methods, but rather to assemble in a single central reference a set of valuable techniques that are used for toxicologic investigations, along with cautionary remarks on their use and limitations.

  • Organophosphates Chemistry, Fate, and Effects

    Chemistry, Fate, and Effects
    • 1 Edición
    • Janice E. Chambers + 1 más
    • Inglés
    This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity.

  • Teratogens

    Chemicals Which Cause Birth Defects
    • 1 Edición
    • Volumen 31
    • V. Kolb Meyers
    • Inglés
    This multi-author work deals with the practical aspects of teratogens - chemicals which cause birth defects. It is designed for use as a unique guide to these chemicals in which one can find all relevant information. The issues covered include: how to obtain information about the teratogenic potential of chemicals; teratogenic chemicals in undergraduate chemistry laboratories; safe handling of teratogenic chemicals; teratogenicity of pesticides and other pollutants in the environment; occupational exposure and pregnancy outcome; identification and prevention of reproductive hazards in industry; and the long-term effects of chemicals on the developing brain. A list of approximately 5,000 chemicals known to cause reproductive effects is given. A comprehensive bibliography is included with each chapter providing up-to-date references for more in-depth coverage. The monograph will be of interest to academic and industrial chemists, health professionals, as well as both undergraduate and graduate students in health and related sciences.

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