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Elsevier

Libros en Toxicología (General)

  • Toxicology Disasters

    Causes and Consequences
    • 1 Edición
    • Sue Ford
    • Inglés
    Toxicology Disasters: Cause and Consequences, a volume in the History of Toxicology and Environmental Health series, provides an historical overview of significant toxicological disasters which involved chemical exposure of humans, animals or the environment. The book documents the timeline of events and the legacy of the resulting exposure which occurred within a specific period of time, but with long lasting consequences. Case studies of toxicological incidents and a wide range of categories, including environmental, industrial, pharmaceutical, domestic and international are not only discussed from a historical perspective but also regarding their impacted toxicology, regulation and our current use of these chemicals.The book will help toxicologists, academics and students from environmental health and toxicology departments, environmental/occupa... health regulators, and industrial hygiene/safety personnel gain a better understanding of the arc of a toxicological disaster from its origins, root causes of the problem, and initial and long-term assessments and management.

  • Mitochondrial Intoxication

    • 2 Edición
    • Marcos Roberto de Oliveira
    • Inglés
    Mitochondrial Intoxication, Second Edition offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology, and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication and challenges of mitochondrial profiling during pre-clinical studies. It then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication. The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, “Mitochondrial Intoxication, Second Edition” offers cutting-edge insights on mitochondrial toxicity, and serves as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Comprehensive Toxicology

    • 4 Edición
    • Charlene McQueen
    • Inglés
    Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems.It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies.

  • Epidemiology of Cannabis

    Genotoxicity, Neurotoxicity, Epigenomics and Aging
    • 1 Edición
    • Albert Stuart Reece + 1 más
    • Inglés
    Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of five areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, cancers, and aging. The book also explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these five areas in detail and applies cutting-edge analytical software and geospatial space–time analytical techniques to these questions. With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.

  • Haschek and Rousseaux's Handbook of Toxicologic Pathology Volume 5: Toxicologic Pathology of Organ Systems

    • 4 Edición
    • Wanda M Haschek + 3 más
    • Inglés
    Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, Volume Five: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals, and biologics. This book continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume Four, and has been completely revised, making it an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

  • Acetaminophen Toxicity

    Experimental and Clinical Advances
    • 1 Edición
    • Barry Rumack + 2 más
    • Inglés
    Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity.Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments.With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.

  • Nonclinical Development of Biologics, Vaccines and Specialty Biologics

    • 2 Edición
    • Lisa M. Plitnick + 1 más
    • Inglés
    Nonclinical Development of Biologics, Vaccines and Specialty Biologics, Second Edition, is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, vaccines, cell and gene therapies, and oncology therapeutics. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. This book discusses the different types of biologics, as well as early characterization strategies, principles of study design, nonclinical pharmacokinetics and pharmacodynamics, nonclinical assays, and regulatory guidelines. A coedited book with chapters authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics.

  • Immunotoxicogenomics

    A Multidisciplinary Approach in Systems Toxicology
    • 1 Edición
    • Md. Naimat Ali + 2 más
    • Inglés
    Immunotoxicogenomics... A Multidisciplinary Approach in Systems Toxicology covers the major mechanisms and effects of toxic substances on the immune system, and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, and emerging and future trends. The book begins with a discussion of the systemic approach to toxicants, but also looks at current genomic tools used to assess immunotoxicity and systems biology methods used in immuno-toxicogenomic... Other topics include genomic expression profiling, gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomic... as a screening tool, and the assessment and analysis of Immunotoxicogenomics data.This book provides a collaborative, multidisciplinary approach for researchers in the fields of toxicology, genetics, immunology, and others engaged in the study on the effects of toxic substances on immune responses.

  • Biomarkers in Environmental and Human Health Biomonitoring

    An Integrated Perspective
    • 1 Edición
    • Ritu Mishra + 3 más
    • Inglés
    Biomarkers in Environmental and Human Health Biomonitoring: An Integrated Perspective provides a holistic view of the biomonitoring of environmental degradation, accumulated toxicity, and associated human health concerns. The book incorporates theoretical and practical aspects of the biomonitoring of environmental pollution and the health surveillance of ecological communities using samples from living organisms which are analyzed for contaminants and toxin levels. In the first half, the book provides a general overview if the different types of biomarkers, their significance as bioindicators for contaminants and detection of toxicity, as well as how they can be utilized in the restoration of degraded ecosystems.The second half of the book discusses molecular biomarkers and how they are used as diagnostic and prognostic tools for pollution monitoring. It also reviews analytical tools used to validate the biomarkers in the detection and monitoring of pollution and disease. Finally, the book delves into how novel approaches like genetic ecotoxicology; Big Data, and artificial intelligence calculates the potential consequences of environmental pollution on the ecosystems and on human health.

  • Public Health and Toxicology Issues in Drug Research, Volume 2

    Toxicity and Toxicodynamics
    • 1 Edición
    • Rakesh K. Tekade
    • Inglés
    Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/tox... the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body.Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.