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Elsevier

Libros en Toxicología

  • Progress in Chemical Toxicology

    Volume 2
    • 1 Edición
    • Abraham Stolman
    • Inglés
    Progress in Chemical Toxicology, Volume 2 reviews significant developments in chemical toxicology, with particular reference to the mode of absorption, distribution, excretion, and metabolism of drugs and poisons in both humans and animals. Some of the techniques for the rapid infrared analysis and identification of gases in human breath are also discussed, along with rapid drug analysis by ion-exchange paper chromatography and ionophoresis. Comprised of six chapters, this volume first deals with the absorption, distribution, and excretion of poisons and their metabolites, including drugs extractable by organic solvents from aqueous acid and alkaline solutions. Subsequent chapters focus on the use of rapid infrared techniques in the detection of volatile organic compounds and toxic gases in humans; rapid methods of toxicological analysis by ion-exchange paper chromatography and ionophoresis; sample preparation and techniques for concentration of metal poisons for increased sensitivity of spectrographic analysis; and application of thin layer chromatography in toxicology. An approach to the analysis of biological specimens for basic drugs is also described. This book will be of interest to chemists and toxicologists.

  • Symposium on Clinical Pharmacology

    Biochemical Pharmacology
    • 1 Edición
    • William A. Creasey + 2 más
    • Inglés
    Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

  • Progress in Chemical Toxicology

    Volume 1
    • 1 Edición
    • Abraham Stolman
    • Inglés
    Progress in Chemical Toxicology, Volume 1 covers the developments in toxicology, including the usefulness of the developed techniques and methods with necessary modifications for toxicological studies. The book describes the isolation and separation techniques for the identification of poisons; the application of gas chromatograph to toxicology; and the pharmacological and toxicological effects aliphatic alcohols. The text also discusses the isolation, purification, identication, and the toxicology of acidic and neutral poisons, ataraxics and nonbarbiturate sedatives. The determination of antiarthritics, antihistamines, and thymoleptics; the physicochemical properties for the identification of narcotics and related bases; and the toxicity of air pollutants are also considered. The book further tackles the analytical methods for air pollutants; the occurrence, symptoms, and treatment of mushroom poisoning; and the toxic components of poisonous seeds and fruits poisonous seeds and fruits. Toxicologists, chemists, and scientists in forensic science laboratories will find the text invaluable.

  • Neuro-Psychopharmacology

    Proceedings of the 11th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Vienna, July 9-14, 1978
    • 1 Edición
    • B. Saletu + 2 más
    • Inglés
    Neuro-psychopharmaco... covers the proceedings of the 11th Congress of the Collegium Internationale Neuro-psychopharmaco... held in Vienna on July 9-14, 1978. The book focuses on the processes, methodologies, and approaches in neuropsychopharmacol... The selection first offers information on the long-lasting effects of electroconvulsive therapy (ECT) on monoaminergic mechanisms and enhanced monoamine behavioral responses following repeated electroconvulsive shock to rats and their relevance to ECT. The book also underscores the ECT effects on mineral metabolism and neuroendocrine function. The publication reviews the genetic components in the mechanism of action of lithium; genetics and lithium ion metabolism in affective disorders; and pharmacogenetics and the pharmacologic challenge strategy in clinical research. The text also examines the influence of peptides in affective disorders and HLA antigens in affective disorders and cycloid psychoses. Discussions also focus on the biological and clinical basis of the therapeutic effects of benzodiazepines; effects of benzodiazepines on the electrical activity of the central nervous system; and diazepam metabolism in healthy subjects and patients with heart failure, renal failure, and hepatic cirrhosis. The selection is a dependable reference for readers interested in neuropsychopharmacol...

  • Sterilisation and Disinfection

    Pharmaceutical Monographs
    • 1 Edición
    • T. D. Whittet + 2 más
    • J. B. Stenlake
    • Inglés
    Pharmaceutical Monographs, Volume 3: Sterilisation and Disinfection provides a strong foundation for the proper use of disinfectants in practice. This monograph surveys the types of preparations required to be produced in a sterile condition and explains in detail the methods available for sterilization. This monograph is comprised of four parts. Part 1 discusses the purposes of sterilizing pharmaceutical preparations to prevent the infection of body tissues, fluids, or cavities with organisms that may produce damage or disease. Part 2 provides information concerning the extent of contamination of pharmaceutical materials, which is obtained by means of sterility tests. Part 3 focuses on autoclave design and an explanation is offered of the background against which sterilizers have been developed and the method in which their major components operate. Part 4 describes the various types of disinfectants, including halogens, phenols, alcohols, aldehydes, dyes, furan derivatives, amidines, surface-active compounds, and derivatives of quinolone and isoquinoline. This monograph is a valuable resource for undergraduate students of pharmacy and allied subjects.

  • Drugs and Enzymes

    Proceedings of The Second International Pharmacological Meeting, Vol. 4
    • 1 Edición
    • Bernard B. Brodie + 1 más
    • Inglés
    Second International Pharmacological Meeting, Volume 4: Drugs and Enzymes is a collection of papers presented at the Second International Pharmacological Meeting on August 20-23, 1963. This volume is organized into two sections encompassing 41 chapters. The first section discusses the relationship between biochemical effects of drugs in vitro and their pharmacological effect in vivo. This section specifically examines the correlation between the action of substances on isolated smooth muscle and on the central nervous system, as well as the behavior of a centrally-acting drug and enzyme in the ion movement in the system. The second section surveys the biochemical mechanisms of drug toxicity. Considerable chapters in this section are devoted to the effect of drug toxicity, such as altered drug metabolism, enzyme induction, morphological changes, hepatic effects, and photosensitivity. This book will prove useful to pharmacologists, neurologists, biochemists, and researchers who are interested the fields of drugs and drug toxicity.

  • Criteria (Dose/Effect Relationships) for Organochlorine Pesticides

    Report of a Working Group of Experts Prepared for the Commission of the European Communities, Directorate-General for Employment and Social Affairs, Health and Safety Directorate
    • 1 Edición
    • M. Mercier
    • Inglés
    Criteria (Dose/Effect Relationships) for Organochlorine Pesticides presents the effect of organochlorine compounds on the immunological processes. This book deals with several organochlorine pesticides. Organized into 15 chapters, this book begins with an overview of the properties and toxicology of dichlorodiphenyl trichloroethane (DDT), a potent non-systemic stomach and contact insecticide of high persistence on solid surface. This text then examines the absorption, metabolism, and excretion of lindane in laboratory animals and in humans as well. Other chapters consider the studies on the carcinogenic potential as well as the mutagenic effects of dieldrin. This book discusses as well the metabolism and pharmacokinetics of endrin, which is a non-systemic and persistent insecticide used primarily on field crops. The final chapter deals with the need for further evaluation of any possible long-term risks to humans from the production and use of the technical product. This book is a valuable resource for agriculturists and research workers.

  • The Scientific Basis of Drug Therapy in Psychiatry

    Proceedings of a Symposium Held at St. Bartholomew's Hospital, London
    • 1 Edición
    • John Marks + 1 más
    • Inglés
    The Scientific Basis of Drug Therapy in Psychiatry is a collection of papers that covers the therapeutic effects and the mode of action of the various psychotropic drugs. The materials in the title are organized thematically based on the topic they tackle. The text first covers the articles on the basic concepts, such as anatomy and physiology of the emotions and their relation to psychoactive drugs, as well as the methods of assessment of psychological effects of drugs. The next three chapters cover the concerns with the psychotropic drugs that include clinical use, mode of actions, and pharmacology. The remaining paper talks about some of the considerations that need to be taken when administering psychotropic drugs. The book will be of great use to researchers and practitioners in behavioral science related disciplines, such as psychology, psychiatry, and neurology. Pharmacologists and medicinal chemists will also benefit from the text.

  • Mechanisms of Drug Toxicity

    Proceedings of the Third International Pharmacological Meeting
    • 1 Edición
    • H. Rašková
    • Inglés
    Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

  • Polydrug Abuse

    The Results of a National Collaborative Study
    • 1 Edición
    • Donald R. Wesson + 2 más
    • Inglés
    Polydrug Abuse: The Results of a National Collaborative Study reports on the findings of a national study of polydrug users, initiated and organized by the Special Action Office of Drug Abuse Prevention. This book provides a comprehensive demographic, sociological, psychological, and medical study of polydrug cases. The chapters in the text cover the varieties and classification of polydrug abusers; an estimation of the magnitude of polydrug abuse; certain central nervous system consequences to chronic drug use; and the impact of polydrug abuse on physicians and other deliverers of health care. Physicians, epidemiologists, drug enforcers, and government policy makers will find the book interesting.

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