The Dual Role of Inflammation in Cancer

1 Edición - 1 de septiembre de 2026
Última edición
Editores: Surajit Pathak, Antara Banerjee
Idioma: Inglés

The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how ch… Leer más

Descripción

The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how chronic inflammation creates a microenvironment that supports tumor growth by promoting cellular proliferation, survival, and migration while suppressing immune responses. It traces historical observations, linking inflammation to cancer while also examining how inflammatory cells and mediators contribute to various stages of tumorigenesis. In addition, it discusses the implications of inflammation on cancer treatment, highlighting the potential of anti-inflammatory agents and immunotherapy in targeting the inflammatory tumor microenvironment.

By elucidating on the intricate relationship between inflammation and cancer, the book aims to pave the way for more effective and personalized cancer treatment strategies. As such, it is a valuable resource for researchers in immunology and oncology.

Puntos claves

Provides a comprehensive understanding of the molecular and cellular mechanisms by which inflammation contributes to tumor initiation, progression, and metastasis
Combines historical perspectives, scientific research, and clinical insights to create a holistic understanding of the complex relationship between inflammation and cancer
Delves into cutting-edge developments, including the latest advancements in cancer immunotherapy and novel approaches to modulating the tumor microenvironment through inflammation modulation

De interès para

Researchers working across the biosciences in the field of oncology and immunology

Índice

1. Introduction to Inflammation and Cancer

2. Chronic Inflammation and Cancer: Epidemiological Evidence

3. The Role of Oxidative Stress in Inflammation-Mediated Cancer Progression

4. Inflammation and Tumor Progression: Signaling Cross-Talk and Therapeutic Resistance

5. Pro-and anti-tumorigenic inflammatory signalling in pancreatic cancer: Mechanistic insights and therapeutic implications

6. Inflammation and Beyond: Complex Roles for TGF-β in the Tumor Microenvironment

7. Cytokines and Chemokines in Tumorigenesis and Their Pro-tumorigenic and Anti-tumorigenic Roles in Cancer Development

8. Role of Proinflammatory Chemokines and cytokines in Tumor growth and metastasis

9. The role of Cancer-Associated Fibroblasts in Inflammation of Cancer

10. Role of Macrophages in Regulating Tumour Angiogenesis: Implications for Cancer Therapy

11. Cancer stem cell signaling and inflammation

12. Tumour Microenvironment and Inflammation

13. Tumour Infiltrating Lymphocytes as Possible Therapeutic Targets

14. Mechanisms of Immune Exhaustion in Cancer: Key Players and Critical Pathways

15. Modulation of Tumor Immunogenicity in cancer prevention and therapy

16. Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy

17. lncRNAs as potential modulators for outcomes of immunotherapy in bladder cancer, a comprehensive review

18. Epigenetic Signaling: Regulation of Inflammation in Cancer

19. Gut microbiome and epigenetic changes in developing inflammation and cancer

20. Interplay of the human microbiome, inflammation and colorectal cancer: Emerging insights and therapeutic prospects

21. Metagenomic and Meta-transcriptomic landscapes in cancer

22. The Inflammatory Landscape of Gynecological Cancers: Pathophysiology, Risk, and Therapeutic Potential

23. The Dual Role of Inflammation in Lung Cancer: Regulation of Tumor Growth via MAPK Pathway

24. Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction

25. Toxicological Responses to Carcinogens: How Inflammation Plays a Dual Role in Cancer Progression

26. Personalized Cancer Treatment: Theranostic and Immunotherapeutic-Based Approaches

Detalles del producto

Edición: 1
Última edición
Publicado: 1 de septiembre de 2026
Idioma: Inglés

Sobre los editores

Surajit Pathak

Prof. Surajit Pathak, PhD, is a professor at Chettinad Academy of Research and Education (CARE), Chennai, India since 2015. He was previously a principal research scientist (2022 June–Dec 2022) at Linkoping University, Linkoping, Sweden. He received his PhD degree from India in 2007 and completed his postdoctoral training (2007–15) from the University of Alabama, United States, the University of Padova, Italy, and the University of Linkoping, Sweden. His current research focuses on “Biomarker discoveries for early detection of colorectal cancer.” He has published more than 100 research articles in peer-reviewed international journals of repute with 2233 citations and 27 H-index. Dr. Pathak has edited Elsevier book “Stem Cells and Aging” in 2021. He is the member of various professional research bodies of India, including the Indian Association of Cancer Research and the Indian Science Congress.

Afiliaciones y experiencia

Professor, Chettinad Hospital and Research Institute, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai, India

Antara Banerjee

Dr. Antara Banerjee, PhD, is presently working as an associate professor at CARE, Chennai from 2016 to date. After completing her PhD in 2008 from India, Dr. Banerjee pursued her postdoctoral work at the University of Padova, Italy and Linkoping University, Sweden (2009–15). She has published over 95 peer-reviewed research articles in international and national journals with citation index-1408 and H-index 19. The Banerjee’s lab at Chettinad Hospital and Research Institute is now focused on understanding the role of mesenchymal stem cells niche in tissue regeneration and exploring signaling pathways in governing stem cell fate. She is the editor of Elsevier book “Stem Cells and Aging” in 2021. She is the member of various professional research bodies, including the Indian Association of Cancer Research and the Indian Science Congress.