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Elsevier

Libros en Ciencias de la Vida

  • Diabetic Neuropathy

    • 1 Edición
    • Shahidul Islam
    • Inglés
    "Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.

  • Blood-Based Biomarkers for Alzheimers and Parkinsons Disease

    • 1 Edición
    • Volumen 191
    • Inglés
    Blood-Based Biomarkers for Alzheimer’s and Parkinson’s Disease, Volume 191 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on the development and application of circulating biomarkers in neurodegenerative disorders. This volume brings together contributions from an international panel of experts, highlighting emerging strategies for early detection, diagnosis, and monitoring of Alzheimer’s and Parkinson’s diseases.Chapters in this release explore a wide range of biomarker modalities, including exosomes, oxidative stress markers, mitochondrial dysfunction indicators, and astrocyte-associated proteins. Additional contributions examine advances in nanomaterial-based detection systems, proteomic approaches, and biofluid-based biosensors, as well as the role of neurofilament light chain and other circulating markers in clinical applications.Further sections address the integration of biomarkers with disease mechanisms, including vascular contributions, microbiome influences, and metabolic and dietary factors. The volume also discusses challenges and opportunities in translating blood-based biomarkers into clinical practice. Together, these chapters provide a comprehensive overview of the evolving landscape of non-invasive biomarkers, making this volume an essential reference for researchers and clinicians in neuroscience and neurodegenerative disease research.

  • Lysosomal Pathophysiology of Parkinson’s Disease

    • 1 Edición
    • Mattia Volta + 1 más
    • Inglés
    Lysosomal Pathophysiology of Parkinson’s Disease delves into the genetic and genomic revelations that have transformed our understanding of Parkinson’s Disease at the molecular level. The book highlights the critical role of the autophagy-lysosome pathway in the disease's pathogenic processes, drawing a comprehensive timeline of disease onset and progression. It offers a detailed examination of how disruptions in this pathway contribute to the hallmarks of Parkinson’s Disease, providing invaluable insights for researchers and clinicians alike. Subsequent chapters extend these insights by comparing Parkinson’s Disease to other neurodegenerative disorders such as Alzheimer’s Disease and Frontotemporal Dementia. By exploring protein pathology and synaptic alterations, the book underscores the broader implications of autophagy-lysosome dysfunction. Additionally, it discusses how the molecular perspectives gleaned from Parkinson’s Disease can inform our understanding of these other conditions, presenting a unified approach to studying neurodegeneration.

  • The Human Nervous System

    • 4 Edición
    • George Paxinos + 2 más
    • Inglés
    The 4th Edition of the classic book The Human Nervous System continues to assemble contributions from world leaders in research on the brain, spinal cord and peripheral nervous system. This book has been edited by the best-known team of brain cartographers, and it has been completely revised to present the cutting edge of human neuroscience. The structure, connections and function are explained in depth, making this book essential to any student or scientist interested in brain anatomy and function.

  • Neurogynecology and Associated Neurological Disorders

    • 1 Edición
    • Vishal Chavda + 2 más
    • Inglés
    Neurogynecology and Associated Neurological Disorders addresses the emerging interdisciplinary field linking neurology and gynecology, focusing on how neurological disorders impact female reproductive health throughout the lifespan. This reference responds to the growing clinical need for integrated understanding and management of conditions such as menstrual migraines, pregnancy-related neuropathies, and menopausal neurological changes. This volume covers foundational neuroanatomy, hormonal influences on neurological function, and specific disorders including headaches, epilepsy, pelvic neuropathies, and mental health conditions related to reproductive stages. It includes clinical guidelines, case studies, diagnostic tools, and treatment protocols tailored to hormonal phases and life stages. The integration of neurobiological mechanisms with gynecological considerations offers readers a robust framework for interdisciplinary collaboration

  • Technology-Assisted Physical Gait Rehabilitation

    How Robotics, Data Science, and Neuroscience are Changing Modern Physical Therapy
    • 1 Edición
    • Tomislav Baček + 3 más
    • Inglés
    Technology-Assisted Physical Gait Rehabilitation: How Robotics, Data Science, and Neuroscience are Changing Modern Physical Therapy explores computational modeling techniques, robotic assistance, data science, and other technological tools and how they can be jointly used in driving and guiding physical gait therapy in impairments such as stroke, traumatic brain injury, and incomplete spinal cord injury. This book gathers experts in robotics, human biomechanics, physical therapy, neuroscience, engineering, and medicine, presenting their ongoing work and discusses their views of the future direction of technology-assisted gait therapy, showcasing the latest advancements in the interdisciplinary and multidisciplinary field of technology-assisted gait therapy and strives to outline the developments in the coming years that are needed/likely to make the next big breakthrough in the field.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1 Edición
    • Deepak Kumar + 4 más
    • Inglés
    Geostatistical Approaches to Environmental and Public Health Issues is a timely and comprehensive examination of how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. As the availability of large-scale spatial and temporal data continues to grow, so too does the demand for advanced tools that can navigate the complexity of real-world phenomena. This volume bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners. Environmental and health-related events—such as air and water pollution, disease outbreaks, nutritional deficits, maternal and child health risks, and exposure to natural hazards like floods, droughts, and earthquakes—are inherently spatial and often uncertain. Traditional statistical models fall short in capturing the intricate patterns and dependencies involved. This book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, the volume highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, it demonstrates how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies. By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty.

  • Animal Models of Disease Part F

    • 1 Edición
    • Volumen 211
    • Inglés
    Animal Models of Disease, Part F, Volume 212 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

  • Gender Affirming Hormone Therapy in Humans

    Evidence from Murine Models
    • 1 Edición
    • Jeffrey David Zajac
    • Inglés
    Gender Affirming Hormone Therapy in Humans: Evidence from Murine Models is an unprecedented reference for scientists, researchers, students and anyone interested in this field of research. The book is a review of the current state of mouse animal models of relevance to transgender health. It's divided into chapters specific for different tissues in which mouse models are described and their relevance to human health is discussed. This is a novel reference summarizing what these models demonstrate about the benefits and risks of GAHT and the most effective and lowest risk approach to treatment. The models suggest applications of this research to human studies and treatment of transgender people. There is an expanding number of transgender people with are few evidence based books that address this field relating to the importance and growing role of murine models.

  • Decision Neuroscience

    • 2 Edición
    • Jean-Claude Dreher
    • Inglés
    Decision Neuroscience: An Integrative Perspective presents the most recent and compelling lesional, neuroimaging, electrophysiological... and computational studies, in combination with hormonal and genetic studies, which have led to a clearer understanding of the neural mechanisms behind reward and decision making. The neural bases of reward and decision-making processes are of critical interest to scientists because of the fundamental role that reward plays in a number of behavioral processes (such as motivation learning, and cognition), and because the neural bases have theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders. This book will constitute a comprehensive update of ground-breaking work addressing fundamental questions about the nature of behavior: how does the brain process reward and how does it make decisions when facing multiple options? And will feature entirely new content, as well as expanded coverage on drug and behavioral addiction, the role of subthalamus stimulation in neurological disorders and neuroeconomics.

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