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Elsevier

Libros en Farmacología Molecular

  • Recent Advances in Molecular Docking

    Methods, Tools, and Applications
    • 1 Edición
    • Khalid Raza
    • Inglés
    Recent Advances in Molecular Docking: Methods, Tools, and Applications offers an authoritative guide to modern molecular docking techniques, emphasizing the integration of artificial intelligence and machine learning. The volume covers foundational principles, computational workflows, and advanced scoring functions, providing researchers and practitioners with practical tools to improve drug-target interaction predictions. It highlights applications across pharmaceuticals, including cancer, neurological disorders, and infectious diseases, which are all supported by real-world case studies. Challenges in docking accuracy, reproducibility, validation, and ethical and regulatory considerations are also covered.Authored by international experts, it bridges theoretical knowledge with practical applications, making it an essential resource for computational biologists, pharmacologists, and drug developers aiming to leverage AI-driven docking in precision medicine.

  • Emerging Trends in Cancer Pharmacology

    From Molecular Targets to Personalized Medicine
    • 1 Edición
    • Tapan Behl + 4 más
    • Inglés
    Emerging Trends in Cancer Pharmacology: From Molecular Targets to Personalized Medicine gives readers a comprehensive and up-to-date resource on the latest developments and trends in the field of cancer pharmacology. It serves as a valuable reference for researchers, scientists, clinicians, and other professionals involved in cancer research, pharmacology, oncology, and personalized medicine. In recent years, there have been significant breakthroughs in understanding the molecular mechanisms of cancer and the development of targeted therapies. Additionally, personalized medicine has emerged as a promising approach to tailor treatments based on an individual's genetic profile, tumor characteristics, and other factors. These developments have the potential to revolutionize cancer treatment and improve patient outcomes. This book covers such developments.

  • Quinone-Based Compounds in Drug Discovery

    Trends and Applications
    • 1 Edición
    • Umar Ali Dar + 2 más
    • Inglés
    Quinone-Based Compounds in Drug Discovery: Trends and Applications provides a comprehensive and up-to-date overview of the latest advances in the field of drug discovery using quinone-based materials. The book covers various aspects of quinone-based materials such as their synthesis, characterization, and applications in drug discovery, consolidating current research. It introduces quinones in the pharmacology context and then describes current developments in drugs for key diseases and conditions. Final chapters deal with the regulatory and commercial framework to take quinone-based drugs to the market.This book will benefit a wide range of readers, including researchers, scientists, and graduate students in the field of drug discovery. Chemists and biochemists will also benefit from the contents of this book.

  • TRP Channels as Therapeutic Targets

    Advances in Basic Science and Clinical Use
    • 2 Edición
    • Arpad Szallasi
    • Inglés
    TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

  • Modulation of Oxidative Stress

    Biochemical, Physiological and Pharmacological Aspects
    • 1 Edición
    • Luciano Saso + 3 más
    • Inglés
    Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

  • Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development

    • 1 Edición
    • Kunal Roy
    • Inglés
    Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development aims at showcasing different structure-based, ligand-based, and machine learning tools currently used in drug design. It also highlights special topics of computational drug design together with the available tools and databases. The integrated presentation of chemometrics, cheminformatics, and machine learning methods under is one of the strengths of the book.The first part of the content is devoted to establishing the foundations of the area. Here recent trends in computational modeling of drugs are presented. Other topics present in this part include QSAR in medicinal chemistry, structure-based methods, chemoinformatics and chemometric approaches, and machine learning methods in drug design. The second part focuses on methods and case studies including molecular descriptors, molecular similarity, structure-based based screening, homology modeling in protein structure predictions, molecular docking, stability of drug receptor interactions, deep learning and support vector machine in drug design. The third part of the book is dedicated to special topics, including dedicated chapters on topics ranging from de design of green pharmaceuticals to computational toxicology. The final part is dedicated to present the available tools and databases, including QSAR databases, free tools and databases in ligand and structure-based drug design, and machine learning resources for drug design. The final chapters discuss different web servers used for identification of various drug candidates.

  • A Pharmacology Primer

    Techniques for More Effective and Strategic Drug Discovery
    • 6 Edición
    • Terry P. Kenakin
    • Inglés
    A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets. With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

  • Monoclonal Antibodies

    Physicochemical Analysis
    • 1 Edición
    • Harleen Kaur + 1 más
    • Inglés
    Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.

  • Naturally Occurring Chemicals against Alzheimer’s Disease

    • 1 Edición
    • Tarun Belwal + 4 más
    • Inglés
    Naturally Occurring Chemicals against Alzheimer’s Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer’s disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations.

  • Clinical Pharmacy Education, Practice and Research

    Clinical Pharmacy, Drug Information, Pharmacovigilance, Pharmacoeconomics and Clinical Research
    • 1 Edición
    • Dixon Thomas
    • Inglés
    Clinical Pharmacy Education, Practice and Research offers readers a solid foundation in clinical pharmacy and related sciences through contributions by 83 leading experts in the field from 25 countries. This book stresses educational approaches that empower pharmacists with patient care and research competencies. The learning objectives and writing style of the book focus on clarifying the concepts comprehensively for a pharmacist, from regular patient counseling to pharmacogenomics practice. It covers all interesting topics a pharmacist should know. This book serves as a basis to standardize and coordinate learning to practice, explaining basics and using self-learning strategies through online resources or other advanced texts. With an educational approach, it guides pharmacy students and pharmacists to learn quickly and apply. Clinical Pharmacy Education, Practice and Research provides an essential foundation for pharmacy students and pharmacists globally.