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Elsevier

Libros en Ciencias Farmacéuticas

  • How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms

    From Bench to the Clinics
    • 1 Edición
    • Neelam Poonia + 2 más
    • Inglés
    How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics provides a comprehensive roadmap for transitioning complex injectable formulations from the laboratory to clinical applications. Offering an exploration of various complex injectables, including liposomal dosage forms, nanoparticles, and microspheres, this book delves into dosage form design, excipient selection, stability studies, and optimization techniques. The book examines manufacturing technologies such as aseptic processing, sterile filtration, and lyophilization, and their applications in producing complex injectables. Discussions on quality control measures, analytical techniques, and quality assurance practices are provided to ensure consistent quality and purity throughout the manufacturing process.Readers will benefit from the expert knowledge and practical insights shared by industry professionals and leading researchers, including successful examples of marketed complex injectables. Highlighting best practices and regulatory requirements, this book offers a comprehensive overview of the guidelines for the development, manufacturing, and commercialization of complex injectables. Ideal for pharmaceutical scientists, formulation developers, and regulatory professionals, this book is a valuable resource for anyone involved in the scale-up and commercialization of complex injectable dosage forms.

  • Antibiotic Resistance and Nanotherapy

    • 1 Edición
    • Awanish Kumar + 1 más
    • Inglés
    Antibiotic Resistance and Nanotherapy is a comprehensive guide that explores an interdisciplinary approach to address the pressing issue of antibiotic resistance and explores the possibility of nanotherapy as a cutting-edge strategy to treat illnesses that are resistant to antibiotics, employing nanoparticles to target and kill bacteria selectively without damaging healthy cells. It details the underlying mechanisms of drug resistance in intracellular and extracellular pathogens and explores the latest advancements in nanotechnology, including the development of innovative nanomaterials and delivery systems that can be utilized to combat antibiotic-resistant infections. This book also discusses the ethical and practical challenges associated with implementing nanotherapy for bacterial resistance. Featuring contributions from experts in the field, this book is an essential resource for researchers, medical professionals, and policymakers seeking to understand and tackle the immediate threat posed by antibiotic resistance.

  • Math Calculations for Pharmacy Technicians

    A Worktext
    • 5 Edición
    • Elaine Beale
    • Inglés
    Master the math skills needed to calculate drug dosages safely and accurately! Math Calculations for Pharmacy Technicians, 5th Edition, covers the competencies required by the American Society of Health-System Pharmacists (ASHP). Designed specifically for pharmacy technicians, the book includes a review of basic math, conversions between measurement systems, interpretation of drug labels and physicians' orders, and calculation of medications based on a patient's age, body weight, or body surface area. Two basic methods of calculating drug dosages are described: ratio/proportion and dimensional analysis. Simplifying calculation concepts, Elaine Beale’s worktext breaks down calculations, provides examples, and contains hundreds of practice problems to help you develop calculation confidence and prepare for a successful career as a pharmacy technician.

  • Harnessing Endogenous Mechanisms for Targeted Drug Delivery

    • 1 Edición
    • Anisha A. D’Souza + 2 más
    • Inglés
    Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

  • Handbook of Pharmaceutical Wet Granulation

    Theory and Practice in a Quality by Design Paradigm
    • 2 Edición
    • Ajit S. Narang + 1 más
    • Inglés
    Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm, Second Edition offers a single and comprehensive reference dedicated to all aspects of pharmaceutical wet granulation, taking a holistic approach by combining introductory principles with practical solutions. Chapters are written by international experts across industry, academic and regulatory settings, and cover a wide spectrum of relevant and contemporary wet granulation topics, techniques and processes. This completely revised and updated edition features five new chapters covering new AI tools applied to scaling up granulation processes, model drive design, machine learning models for granule property prediction, design and scale up of fluid bed granulation, and process analytical methods. This book is the prefect reference for pharmaceutical manufacturing professionals. Academic researchers will benefit from the practical advice provided by the editors and chapter authors.

  • Side Effects of Drugs Annual

    • 1 Edición
    • Volumen 47
    • Inglés
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 47, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered include ADRs, ADEs and SEDs: A Bird’s Eye View, Lithium, Drugs of abuse, Side effects of drugs used in the treatment of Alzheimer's disease, Sedatives and hypnotics, Antipsychotic agents, Anti-epileptic Medications, Side effects of opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, Side effects of local anesthetics and therapeutic gases, and more.Other sections covered include Antihistamines (H1 receptor antagonists), Drugs that act on the respiratory tract, Positive inotropic drugs and drugs used in dysrhythmias, Beta adrenergic antagonists and antianginal drugs, Drugs acting on the cerebral and peripheral circulations, Antihypertensive drugs, and much much more.

  • Functionalized Drug Delivery Systems

    • 1 Edición
    • Umesh Gupta + 1 más
    • Inglés
    Functionalized Drug Delivery Systems delves into the potential of various functionalized drug delivery systems, such as polymeric micelles, dendrimers, metallic nanoparticles, and SMEDDS. It offers a comprehensive guide from basic concepts to advanced surface engineering techniques. The book covers liposomes, dendrimers, metal nanoparticles, polymeric micelles, niosomes, and ethosomes, concluding with a chapter on the regulatory framework. This invaluable resource is perfect for pharmaceutical researchers and graduate students keen on advancing their understanding and application of these innovative drug delivery methods. The book also provides consolidated literature reviews, making it a foundational text for new researchers.Its chapters are dedicated to specific techniques, offering detailed insights into each method. Readers will gain knowledge on improving drug absorption and targeted delivery, supported by practical examples and case studies. The final chapter on regulatory frameworks ensures compliance and best practices in developing functionalized drug delivery systems. This book is an essential read for anyone in the field of pharmaceutical research.

  • Fundamentals and Design of Drug Delivery Systems

    A Textbook with Lab Activities
    • 1 Edición
    • Wujie Zhang
    • Inglés
    Fundamentals and Design of Drug Delivery Systems: A Textbook with Lab Activities is an essential resource for pharmaceutical sciences and engineering students. Covering all key concepts related to drug delivery courses, it introduces basic pharmacology, barriers to drug delivery, drug targeting, and novel drug delivery systems. Design considerations and approaches are thoroughly illustrated. The textbook reflects nanotechnology in various chapters and includes practical lab activities, providing a comprehensive understanding of drug delivery systems, experimental design, and data analysis. It is ideally suited for upper-undergraduate and graduate courses.In addition to the foundational material, the textbook delves into cutting-edge topics such as biomimetic drug delivery systems, targeted delivery systems, stimuli-responsive systems, and micro/nano-robots-ba... drug delivery systems. Emerging fields like cell therapy, artificial intelligence (AI) in drug delivery, and 3D printing-based systems are also explored. Professionals in the Pharma industry will benefit from the innovative concepts and platforms presented, making it a valuable addition to their resources.

  • Dissipative Particle Dynamics

    Fundamentals and Applications in Soft Matter Science and Engineering
    • 1 Edición
    • Alexander V. Neimark + 1 más
    • Inglés
    Dissipative Particle Dynamics: Fundamentals and Applications in Soft Matter Science and Engineering comprehensively presents the fundamentals of dissipative particle dynamics (DPD) theoretical formulations and computational strategies, providing practical guidance on the application of DPD models to various colloidal and interfacial phenomena involving phase separations, self-assembly and transport in complex fluids, polymeric, surfactant, nanoparticle, and biological systems. In addition, the book contains instructive advice on efficient implementation of the DPD models in open-source computational packages. Since the introduction of the principles of DPD methodology, multiple efforts have been made to improve the computational basis of DPD, and to devise advanced versions and modifications. There are numerous research papers on this topic, but no books until now. Readers will find this to be a comprehensive reference source of multifaceted, interdisciplinary applications that provides practical guidance for efficient computational implementation.

  • Inorganic Biomaterials for Drug Delivery

    • 1 Edición
    • Amit Kumar Nayak + 2 más
    • Inglés
    Inorganic Biomaterials for Drug Delivery covers a wide range of inorganic biomaterial types and their properties, from traditional materials like ceramics, metallics, and bioglasses to novel composites and nano-engineered inorganic biomaterials. Biocompatibility, toxicity, and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science, pharmacology, chemical engineering, and clinical science.

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