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Elsevier

Libros en Ciencias Farmacéuticas

  • Basic Principles of Drug Discovery and Development

    • 3 Edición
    • Benjamin E. Blass
    • Inglés
    **Selected for 2026 Doody's Core Titles in Pharmacy**Basic Principles of Drug Discovery and Development, Third Edition presents a unique overview of the drug discovery and development program not available elsewhere. Each chapter provides sufficient technical details on the topics covered so that non-experts will have the tools and information necessary to interact and exchange information with colleagues across the entire spectrum of the drug discovery and development process. The drug discovery and development process involves individuals and teams with a wide array of expertise ranging from basic sciences (medicinal chemistry, biology) to applied science (pharmacology, pharmacokinetics, clinical sciences) to business driven fields (regulatory affairs, intellectual property experts, marketing specialists).The success or failure of a program focused on bringing a new medication to market often depends on clear communication between individuals and teams with vastly different expertise. As a result, it is critical that experts in one aspect of drug discovery and development (e.g., medicinal chemists) have a working understanding of the wide range of disciplines that take part in the overall process.

  • Cell Free Synthesis of Biologics

    A Comprehensive Guide
    • 1 Edición
    • Sarfaraz Niazi
    • Inglés
    Cell Free Synthesis of Biologics: A Comprehensive Guide addresses the need for efficient production methods in biopharmaceutical manufacturing. As the demand for biologics continues to rise, traditional cell-based production systems often fall short due to high costs and complexity. This book offers a detailed exploration of cell-free protein synthesis (CFPS), providing researchers and professionals with the latest methodologies, best practices, and troubleshooting strategies necessary for successful implementation. The content is structured into comprehensive chapters that cover the historical development, technical foundations, optimization strategies, advanced technologies, and the regulatory landscape surrounding CFPS.Each section is designed to guide users through the complexities of establishing and scaling up cell-free systems, ensuring a clear understanding of the processes involved and the potential applications in therapeutic development, diagnostics, and industrial biotechnology. This book provides pharmaceutical scientists and pharma manufacturing professionals with practical insights and innovative strategies to enhance efficiency and reduce costs in biopharmaceutical production.

  • The Future of Pharma Across All Sectors in the Artificial Intelligence Era

    • 1 Edición
    • Miltiadis Lytras + 5 más
    • Inglés
    The Future of Pharma Across All Sectors in the Artificial Intelligence Era offers a thorough examination of the pharmaceutical industry's current landscape, highlighting the myriad challenges, opportunities, and trends that are poised to shape its future. Edited by experts, this book delves into transformative technological advancements, including artificial intelligence, machine learning, big data analytics, and blockchain. These technologies are redefining pharmaceutical research, development, and commercialization, making precision medicine and personalized therapies a reality, while integrating genomic medicine into the pharmaceutical value chain.Additionally, the book addresses educational implications for academic curricula, emphasizing the need for digital transformation in healthcare delivery models. It scrutinizes regulatory trends and compliance, offering insights into navigating complex landscapes to ensure product quality and safety. The book emphasizes the pharmaceutical industry's role in tackling infectious diseases and health disparities, promoting health equity through innovative drug development and access initiatives. Future trends and predictions are speculated upon, considering demographic shifts and evolving healthcare needs, while market dynamics and commercial strategies are analyzed to equip pharmaceutical companies with practical recommendations for navigating competitive landscapes.

  • CDK4/6 inhibitors in Breast Cancer Therapy

    • 1 Edición
    • Pankaj Kumar Singh + 3 más
    • Inglés
    CDK4/6 inhibitors in Breast Cancer Therapy examines the pivotal role of CDK4/6 inhibition in treating hormone receptor-positive (HR+)/HER2-negative advanced breast cancer. The book highlights FDA-approved applications of these inhibitors alongside endocrine therapy and explores ongoing research into their potential as neoadjuvant treatments. It provides insights into the drug discovery and development of CDK4/6 inhibitors, covering their molecular mechanisms, pharmacology, and clinical applications. Chapters address their use in mono and adjuvant therapies, as well as challenges in targeting, while also discussing market potential and post-marketing safety issues.This book is a valuable resource for researchers and academics, enhancing understanding of CDK4/6 inhibitors' chemistry and therapeutic implications. By presenting detailed information on clinical trials and market formulations, it equips the audience with essential knowledge to navigate the complexities of targeted breast cancer therapies and contributes to advancing research in this critical area.

  • Advanced Cancer Therapeutics

    Strategies and Technologies for Targeted Drug Delivery
    • 1 Edición
    • Manish Kumar + 2 más
    • Inglés
    Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.

  • Contemporary Research Methods in Pharmacy and Health Services - Volume 2

    • 1 Edición
    • Aleda M. H. Chen + 5 más
    • Inglés
    Contemporary Research Methods in Pharmacy and Health Services, Volume Two is an essential resource for researchers and practitioners in the field of pharmaceutical science. Building on the groundbreaking work published in the esteemed journals Research in Social and Administrative Pharmacy (RSAP) and Exploratory Research in Clinical and Social Pharmacy (ERCSP), this volume addresses the critical need for comprehensive and structured methodologies in evaluating and implementing pharmacy services. By transforming selected articles into fully developed chapters, the book enriches the discourse surrounding contemporary research methods, making it an invaluable tool for advancing knowledge and practice.The volume features a diverse array of chapters that cover a wide range of topics, including the use of the Consolidated Framework for Implementation Research (CFIR) to evaluate telepharmacy services for outpatient cancer patients, the translation and validation of adherence measurement tools, and the application of network analysis in health code systems. Other notable contributions explore innovative strategies for improving clinical pharmacy services, conducting scoping reviews in pharmacy education, and employing mixed-methods approaches to enhance medication counseling.

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1 Edición
    • Chris Van Der Walle
    • Inglés
    Interest in gene and cell therapies has increased dramatically following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access. Gene and Cell Therapies: Principles of Pharmaceutical Development provides insight to the key principles of emerging scientific and technical strategies to overcome these obstacles. How the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, autologous and allogeneic cell therapies, impacts their pharmaceutical development is outlined. The advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are related to the process and analytical developments that ensure their quality. The scope and style, along with included case studies, learning points and lecture slides, will allow the non-specialist to develop a foundational understanding, while the contemporary concepts discussed will urge further advancement of these exciting medicines.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1 Edición
    • Lalit Kumar + 2 más
    • Inglés
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • Advancing Integrative Medicine Through Medical Intelligence

    Introduction to Medical Intelligence with Integrative Medicine
    • 1 Edición
    • M. Sumbul + 1 más
    • Inglés
    Advancing Integrative Medicine Through Medical Intelligence: Introduction to Medical Intelligence with Integrative Medicine explores the synergy between advanced technologies like AI, data analytics, and traditional medicine. This comprehensive book examines how these fields converge to enhance healthcare outcomes by covering key topics such as the role of AI in modern medicine, the integration of traditional practices like Ayurveda and Unani with AI, and holistic approaches for patient care. It also includes AI-assisted mental health interventions, disease prevention through traditional methods, and AI in diagnosing chronic diseases and managing pain.Academics, researchers, and healthcare professionals will find this book invaluable for understanding how to combine AI and integrative medicine to improve health outcomes. It offers practical case studies and explores emerging trends that will shape the future of healthcare, making it a crucial resource for those interested in the evolving landscape of medical practices.

  • Innovative Nanocarriers for Stimulated Drug Delivery

    A Comprehensive Guide to Stimuli-responsive Nanoparticles
    • 1 Edición
    • Prashant Kesharwani
    • Inglés
    Innovative Nanocarriers for Stimulated Drug Delivery: A Comprehensive Guide to Stimuli-responsive Nanoparticles summarizes recent advances and achievements in nanocarriers responsive to external or internal stimuli. The book presents different stimuli-sensitive strategies and their applications in drug delivery, therapy, and theranostics. Sections provide fundamental knowledge on the experiential and experimental aspects of stimuli-responsive nanocarriers, discuss external-responsive nanocarriers for biomedical applications, such as ultrasound, thermal, magnetic, light, and electric field-response systems, and describe internal stimuli-responsive nanocarriers for biomedical applications, including pH, hypoxia, redox potential, enzyme, glucose, and microRNA-responsive nanocarriers. Additionally, the book covers dual and multimodal-responsiv... nanocarriers and the therapeutic aspects of stimuli-responsive nanocarriers, such as metallic and non-metallic stimuli-responsive nanocarriers in the treatment of various cancer and noncancerous diseases. Finally, recent advances and regulatory aspects of stimuli-responsive nanocarriers, including clinical translation, challenges, biological toxicity, safety issues, clinical trials, and future perspectives are covered.

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