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Elsevier

Libros en Neurociencia del Desarrollo y Regeneración

  • Gold Nanoparticle Therapeutics in Alzheimer's Disease

    Revolutionizing Diagnosis and Treatment
    • 1 Edición
    • Arun Kumar Singh + 2 más
    • Inglés
    Gold Nanoparticle Therapeutics in Alzheimer's Disease: Revolutionizing Diagnosis and Treatment is an essential resource that delves into the groundbreaking use of nanotechnology in the fight against one of the most challenging neurodegenerative disorders. This volume offers an in-depth exploration on how gold nanoparticles can be used to enhance the diagnosis, treatment, and overall understanding of Alzheimer's disease. By examining the molecular mechanisms that enable nanoparticles to cross the blood-brain barrier, the book highlights their role in inhibiting amyloid fibrils and their potential as precise diagnostic tools.Covering a wide range of topics, this comprehensive guide serves as an invaluable reference for researchers, clinicians, and industry professionals at the forefront of Alzheimer's research and nanomedicine.

  • Aggressive Behavior of People with Autism and other Intellectual and Developmental Disability

    • 1 Edición
    • Lauren Charlot + 1 más
    • Inglés
    Aggressive Behavior of People with Autism and other Intellectual and Developmental Disability explores the primary factors influencing the occurrence of aggression in autistic people, offering practical suggestions for improving outcomes. Topics covered include understanding the effects of neurodevelopmental disorders, multiple factors that frequently impact the risk for aggression, common medical and neurological influences, and the effects of trauma. The book will also introduce a new model for integrating multiple influences into a contextual, functional behavior assessment.While people with autism and other intellectual and developmental disabilities receive extensive services for their behavioral health needs, many continue to struggle and lack a positive quality of life. This book covers these occurrences and the primary factors governing aggression and other externalizing behaviors.

  • Protein Serine/Threonine Kinases in Neurodegenerative Disorders

    • 1 Edición
    • Heba Mohamed Mansour + 1 más
    • Inglés
    Protein Serine/Threonine Kinases in Neurodegenerative Disorders provides a comprehensive overview of protein serine/threonine kinases (STKs) in health and disease. It also discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. This book begins with an introduction to protein kinases and inhibitors, followed by detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARKs), mammalian target of rapamycin (mTOR), leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), and dual-specificity tyrosine phosphorylation-regu... kinase (DYRK), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms.This book features 23 chapters written by renowned experts in the field of kinases. It explores novel targets modulated by protein kinases, including noncoding RNAs (ncRNAs) and mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their role of metabolic regulation in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson’s disease, are also examined. This book sheds light on bioactive compounds from natural products that target kinases. This book explains the role of different kinases in various pathogenic pathways and mechanisms involved in neurodegeneration, including regulated cell death, autophagy, synaptic dysfunction, and neuroinflammation. It also discusses splicing kinases in regulating splicing factor phosphorylation and details how aberrant kinase activity leads to splicing defects that contribute to neurodegenerative pathologies. This book emphasizes bridging laboratory research with clinical applications, focusing on translational opportunities. It includes insights from FDA regulatory experts on therapeutic applications and safety considerations of targeting kinases, highlighting the importance of balancing efficacy and safety, particularly in relation to drug-induced liver injury associated with kinase inhibitors. Finally, this book discusses the obstacles and opportunities for the potential repositioning of protein kinase inhibitors in neurodegenerative disorders

  • Heavy Metal Toxicity and Neurodegeneration

    • 1 Edición
    • Prasann Kumar + 1 más
    • Inglés
    Heavy Metal Toxicity and Neurodegeneration delves into the intricate relationship between heavy metals and neurodegenerative diseases. It synthesizes and presents the latest research findings, shedding light on the mechanisms by which heavy metals cause neuronal damage and contribute to disease progression. By integrating various perspectives and collating diverse studies, this book serves as an invaluable resource for those seeking to understand the profound impact of heavy metals on neurological health. In addition to detailing the mechanisms involved, the book highlights the importance of early detection and preventive measures.It caters to researchers, clinicians, policymakers, and students, offering a comprehensive and accessible overview that bridges the gap between theory and practical application. This scholarly work is poised to inform and guide future research and policy decisions in the field of neurodegenerative disease.

  • Developmental Dyscalculia

    From Brain Mechanisms to Educational Applications
    • 1 Edición
    • Yarden Gliksman + 2 más
    • Inglés
    Developmental Dyscalculia: From Brain Mechanisms to Educational Applications presents research with a domain-general approach. It examines issues in the fields of numerical and non-numerical cognitive domains, neuro- mechanisms, and pedagogic issues to pave the way to a bridge between lab research, daily life, and curriculum applications, with a goal of finding a pathway to early diagnosis and interventions of developmental dyscalculia. It will be of interest to researchers with interests in cognitive neuroscience and education, to contribute fruitful discussions between education and neuro-cognition. 

  • Capute and Accardo's Neurodevelopmental Disabilities in Infancy and Childhood

    • 4 Edición
    • Fatima Y Ismail + 2 más
    • Inglés
    **Selected for 2026 Doody's Core Titles in Neurology**Capute and Accardo’s Neurodevelopmental Disabilities in Infancy and Childhood, Fourth Edition provides updated foundational, theoretical, and practical knowledge on the spectrum and continuum of neurodevelopmental disabilities shaped by ongoing advances in neuroscience and related disciplines. It reviews the over-arching principles of assessment, diagnosis, and management of patients with a wide range of neurodevelopmental disabilities. Streamlined or fully rewritten chapters, including developmental screening and surveillance, neuroimaging and genetic evaluation, early intervention, principles of pharmacological treatment, principles of successful management programs, aging and transition planning, telemedicine and care in low-resource settings are included.The book's practical, expert-led approach aims to prepare future clinicians to skillfully assess and manage children with neurodevelopmental disabilities with the aid of clinical approach flowcharts to common presentations, diagnostic algorithms and clinic notes templates.

  • The Neurodegeneration Revolution

    Emerging Therapies and Sustainable Solutions
    • 1 Edición
    • Trideva Sastri Koduru + 3 más
    • Inglés
    The Neurodegeneration Revolution: Emerging Therapies and Sustainable Solutions provides insights into the mechanics, characteristics, behavior, application, and manufacturing of advanced materials such as nanowires, 2D materials, biomaterials, smart materials, and more. The first section discusses the mechanics and electronic and magnetic properties of nanomaterials, photonic, and photonic materials and devices, 2D magnetic materials, smart materials and coatings, metamaterials, and microdevices and sensors. The second section of the book covers manufacturing technologies and methods of previously discussed materials, outlining manufacturing techniques for additive manufacturing of metallic lattice structures, biomedical alloys, shape memory alloys, multifunctional polymer composites, nanocomposite structures, ceramics, and batteries.

  • Genome Editing for Neurodegenerative Diseases

    From Concept to Clinical Trials
    • 1 Edición
    • Sandeep Kumar Singh + 3 más
    • Inglés
    Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.

  • From Brain Dynamics to the Mind

    Spatiotemporal Neuroscience
    • 1 Edición
    • Georg Northoff
    • Inglés
    From Brain Dynamics to the Mind: Spatiotemporal Neuroscience explores how the self and consciousness is related to neural events. Sections in the book cover existing models used to describe the mind/brain problem, recent research on brain mechanisms and processes and what they tell us about the self, consciousness and psychiatric disorders. The book presents a spatiotemporal approach to understanding the brain and the implications for artificial intelligence, novel therapies for psychiatric disorders, and for ethical, societal and philosophical issues. Pulling concepts from neuroscience, psychology and philosophy, the book presents a modern and complete look at what we know, what we can surmise, and what we may never know about the distinction between brain and mind.

  • Adolescent Psychosis

    Clinical and Scientific Perspectives
    • 1 Edición
    • Ingrid Agartz + 1 más
    • Inglés
    Adolescent Psychosis: Clinical and Scientific Perspectives presents new methodologies and novel scientific findings, with a comprehensive orientation into the genetics, phenomenology, nosology, and long-term outcome of adolescent early-onset psychosis research. This volume discusses recent epidemiological studies, along with co-morbid aspects associated with other neurodevelopmental syndromes and somatic diseases. The book also provides suggestions for future research using a translational perspective, from genes to the clinic to and relevant phenotypes, biomarkers, treatment options and etiological aspects. Topics discussed bring together expert researchers in the field to represent different perspectives and future possibilities.