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Elsevier

Libros en Microbiología y Virología

  • Advances in Cancer Research

    • 1 Edición
    • Volumen 68
    • Inglés
    Volume 68 of Advances in Cancer Research continues the tradition of publishing up-to-date reviews and "hot" topics in cancer research. This volume begins with a "Foundations in Cancer Research" article by Harald zur Hausen that reviews his years of research on the idea that cancer can be triggered by infection. The structure and function of the cytokine receptor superfamily and its association with leukemias are discussed in depth by James Ihle. Marcia Hall and Gordon Peters review the evidence indicating that genetic abnormalities hinder the function of certain cyclins and their inhibitors. The most widely studied protooncogene, c-myc, is reviewed by Marie Henriksson and Bernhard Lüscher; the chapter focuses on the function of c-myc as a transcription factor rather than on the effects of gene translocation and activation on malignancies. Ham Werner and Derek LeRoith present data on the role that insulin-like growth factors play on cell growth and regulation. In the final chapter, Olli-P. Kallioniemi and Tapio Visakorpi investigate the field of prostate cancer and, more importantly, the biological reason and natural history behind the growth of this cancer.

  • Advances in Antiviral Drug Design

    • 1 Edición
    • Volumen 2
    • E. De Clercq
    • Inglés
    The purpose of the series on Advances in Antiviral Drug Design is to regularly review the "state of the art" on emerging new developments in the antiviral drug research field, thereby spanning the conceptual design and chemical synthesis of new antiviral compounds, their structure-activity relationship, mechanism and target(s) of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use. Volume 2 begins with a description of the antiviral potential of antisense oligonucleotides by J. Temsamani and S. Agrawal. According to the aims of the anitsense technology, these oligonucleotides should be targeted at specific viral antisense technology, these oligonucleotides should be targeted at specific viral mRNA sequences so that translation to the virus-specified proteins is blocked; this has been achieved for a number of oligomers, some of which are now in clinical trials for the treatment of HIV, HCMV, and human papilloma virus (HPV) infections. Then C.-S. Yuan, S. Liu, S.F. Wnuk, M.J. Robins and R.T. Borchardt assess the role of S-adenosylhornocyste... (AdoHcy) hydrolase as target for the design of antiviral agents with broad-spectrum antiviral activity. This is followed by an in-depth account on the design and synthesis of a number of first-, second- and third-generation AdoHcy hydrolase inhibitors and their mode of action at the enzyme level.V.E. Marquez provides a comprehensive description of the various carbocyclic (carba) nucleosides that have been synthesized and evaluated for antiviral activity. Although the number and diversity of the carba-nucleosides that have been found to be antivirally active (or inactive) is astonishingly high, there is no limit to further expansion of this fascinating class of molecules. For the various nucleoside analogues that have to be intracellularly phosphorylated to the 5'-triphosphate stage, to interact with their target enzyme (i.e., herpesviral DNA polymerase or retroviral revers transcriptase) the first phosphorylation step is often the rate-limiting step, and thus various strategies are envisaged by C. Perigoud, J.-L. Girardet, G. Gosselin and J.-L. Bach on how to bypass this initial phosphorylation and to deliver the nucleoside 5'-monophophate directly inside the cells.The HIV protease has been considered as a paradigm for rational drug design. The enzyme is among the best understood in terms of both structure and action, and because of its crucial role in the maturation of HIV, it has been vigorously pursued as a target for anti-HIV chemotherapy. In their comprehensive review of the multidisciplinary approach towards the development of HIV protease inhibitors A.G. Tomasselli, S. Thaisrivongs and R.L. Heinrikson highlight those protease inhibitors which have been brought forward to clinical trials.

  • Virology Methods Manual

    • 1 Edición
    • Hillar O. Kangro + 1 más
    • Inglés
    The Virology Methods Manual is a comprehensive source of methods for the study, manipulation, and detection of viruses. Edited by Brian Mahy and Hillar Kangro, this work describes the most up-to-date, definitive techniques, provided by experts in each area, and presented with easy-to-use, step-by-step protocols. This new manual will satisfy the needs of virologists and all those working with viruses who need a practical guide to methods that work!

  • The Chaperonins

    • 1 Edición
    • Robert L. Ellis
    • Inglés
    The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 37
    • Inglés
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • Crystalline Bacterial Cell Surface Proteins

    • 1 Edición
    • Uwe B. Sleytr + 3 más
    • Inglés
    Crystalline Bacterial Cell Surface Proteins assembles information on the understanding of the occurrence, structure, chemistry, genetics, assembly, function, and application potential of S-layers. The chapters are designed to stand independent of each other and provide a complete survey of the different topics in S-layer research. This book is intended to stimulate further development in basic and applied S-layer research.

  • Molecular and Diagnostic Procedures in Mycoplasmology

    Diagnostic Procedures
    • 2 Edición
    • Inglés
    This book and its companion, Volume I, concentrate on new procedures--especial... those based on the new molecular methodology--develop... within the past decade. This volume deals with the new genetic and immunological tools applied to the diagnosis of mycoplasma infections of humans, animals, plants, insects, and all cultures. Volume I outlines the approaches, techniques, and procedures applied to cell and molecular biology studies of mycoplasmas.

  • Advances in Virus Research

    • 1 Edición
    • Volumen 46
    • Inglés

  • Molecular and Diagnostic Procedures in Mycoplasmology

    Molecular Characterization
    • 1 Edición
    • Inglés
    This book and its companion, Volume II, concentrate on new procedures--especial... those based on the new molecular methodology--develop... within the past decade. This volume outlines the approaches, techniques, and procedures applied to cell and molecular biology studies of mycoplasmas. Volume II deals with the new genetic and immunological tools applied to the diagnosis of mycoplasma infections of humans, animals, plants, insects, and all cultures, with particular emphasis on the association of mycoplasmas with the activation of AIDS.

  • Advances in Microbial Physiology

    • 1 Edición
    • Volumen 37
    • Inglés
    Praise for the Serial"This series has consistently presented a well-balanced account if progress in microbial physiology...Invalua... for teaching purposes."- AMERICAN SCIENTISTAdvances in Microbial Physiology was first published in 1967, and under the pioneering editorship of Professor Tony Rose, with the collaboration at various times of John Wilkinson, Gareth Morris and Dave Tempest, the series has become immensely successful and influential. The editors have always striven to interpret microbial physiology in the broadest possible context and have never restricted the contents to "traditional" views of whole cell physiology.Robert Poole was appointed as the new editor following the untimely death of Tony Rose. Under Professor Poole's editorship, Advances in Microbial Physiology continues to publish topical and important reviews, and to interpret physiology as widely as in the past by including all material that contributes to the understanding of how microorganisms and their component parts work. This continues to be the real challenge of microbial physiology.

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