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Elsevier

Libros en Microbiología y Virología

  • Advances in Antiviral Drug Design

    • 1 Edición
    • Volumen 4
    • E. De Clercq
    • Inglés
    The fourth volume of Advances in Antiviral Drug Design is keeping up with the recent progress made in the broad field of antiviral drug research and encompasses six specific directions that have opened new avenues for the treatment of HIV and other virus infections.First, as the introductory chapter, the different new anti-HIV agents that are now in preclinical or clinical development are reviewed by E. De Clercq. This includes new NRTIs, NNRTIs and PIs, but also HIV entry/fusion inhibitors as well as integrase inhibitors, and some of these agents, such as the NRTI emtricitabine [(-)FTC] and the PI atazanavir, may soon be licensed for clinical use.Second, high expectations are vested in the potential therapeutic usefulness of inhibitors of HIV integration, a point of no return in the life cycle of HIV, and this approach is highlighted by D.J. Hazuda and S.D. Young.Third, as all currently available PIs can be described as "peptidomimetic", and, therefore, expected to demonstrate overlapping virus-drug resistance and side effect profiles, it would be interesting to see how a non-peptidic protease inhibitor such as tipranavir behaves, and this is covered by D. Mayers, K. Curry, V. Kohlbrenner and S. McCallister.Fourth, neuraminidase inhibitors such as zanamivir (that has to be inhaled) and oseltamivir (that can be administered via the oral route) have gained a definitive status as antiviral drugs useful for both therapy and prophylaxis of influenza A and B virus infections; as they target a specific influenza viral enzyme, neuraminidase (or sialidase), they may be expected to block newly emerging influenza viruses as well, and the design of neuraminidase inhibitors has received due attention of H. Jin and C.U. Kim.Fifth, while the major current efforts in antiviral drug development have shifted from herpesviruses towards HIV and hepatitis viruses [hepatitis B virus (HBV), hepatitis C virus (HCV)], it is interesting to note that by switching from the classical five-membered sugar or acyclic nucleoside strategy, J. Wang, M. Froeyen and P. Herdewijn have gone "upstream" in designing six-membered carbocyclic nucleosides as potential anti-herpesvirus agents.Sixth, following up on the nucleotide prodrug strategy introduced above under ix, to deliver the biologically active nucleotides inside the cells, C. Meier has elaborated on a particular class of such pronucleotides, namely that of the cyclosaligenyl pronucleotides, an approach that should have far reaching implications for compounds effective against HIV, HBV and other viruses.The six topics covered in this fourth volume of Advances in Antiviral Drug Design are in the front line of the present endeavors towards the design and development of new therapeutic agents for virus infections. They pertain to the combat against three of the most important viral pathogens of current times: HIV, HBV, influenza virus and herpesviruses.

  • Advances in Microbial Physiology

    • 1 Edición
    • Volumen 48
    • Inglés
    First published in 1967, Advances in Microbial Physiology is one of Academic Press's most renowned and acclaimed series. The Editors have always striven to provide a diverse range of top-quality papers on all aspects of microbial physiology. Coverage of 'holistic' topics or whole cell studies such as ion fluxes, stress responses and motility have gone hand-in-hand with detailed biochemical analyses of individual transport systems, electron transport pathways and many aspects of metabolism. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to publish topical and important reviews, interpreting physiology in its broadest context, to include all material that contributes to our understanding of how microorganisms and their component parts work. In 1999, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 5.35, with a half life of 8 years, placing it 5th in the highly competitive category of Microbiology; testimony to the high regard in which it is held.

  • Frontiers in Viral Hepatitis

    • 1 Edición
    • R.F. Schinazi + 2 más
    • Inglés
    Frontiers in Viral Hepatitis provides a compilation of the research from over 40 key opinion leaders in the field of Hepatitis. The book focuses on the latest advances in the search for new, more effective therapeutic options and related topics in viral hepatitis. These include regulatory issues, epidemiology, and emerging viruses; immunology and vaccines; viral hepatitis B and C infections in children; genetics pathology and viral diagnosis; cell systems and animal models; novel therapeutics for hepatitis B and C; resistance and therapeutic strategies in humans; and prevention and treatment options for hepatocellular carcinoma.The breadth of information published in this volume provides insight into current prevention and treatment options. Recent advances in our understanding of the molecular biology, immunology and pathogenesis of hepatitis viruses have accelerated at a remarkable rate, offering a more comprehensive perspective on hepatitis.

  • Desk Encyclopedia of Microbiology

    • 1 Edición
    • Moselio Schaechter
    • Inglés
    The Desk Encyclopedia of Microbiology aims to provide an affordable and ready access to a large variety of microbiological topics within one set of covers. This handy desk-top reference brings together an outstanding collection of work by the top scientists in the field. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field.

  • The Flaviviruses: Structure, Replication and Evolution

    • 1 Edición
    • Volumen 59
    • Inglés
    Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

  • The Evolution of Parasitism - A Phylogenetic Perspective

    • 1 Edición
    • Volumen 54
    • Inglés
    Parasitology continues to benefit from taking an evolutionary approach to its study. Tree construction, character-mapping, tree-based evolutionary interpretation, and other developments in molecular and morphological phylogenetics have had a profound influence and have shed new light on the very nature of host-parasite relations and their coevolution. Life cycle complexity, parasite ecology and the origins and evolution of parasitism itself are all underpinned by an understanding of phylogeny. The Evolution of Parasitism - A Phylogenetic Perspective aims to bring together a range of articles that exemplifies the phylogenetic approach as applied to various disciplines within parasitology and as applied by parasitologists. Unified by the use of phylogenies, this book tackles a wide variety of parasite-specific biological problems across a diverse range of taxa.

  • Antiviral Nucleosides

    Chiral Synthesis and Chemotherapy
    • 1 Edición
    • C.K. Chu
    • Inglés
    • Up-to-date review on the chemistry and biology of nucleosides• Modern synthetic methodology• Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.

  • Advances in Parasitology

    • 1 Edición
    • Volumen 53
    • Inglés
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Now edited by J.R. Baker, R. Muller, and D. Rollinson, and supported by an international editorial board, Advances in Parasitology includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and reviews of more traditional areas, such as zoology, taxonomy, and life history. Eclectic volumes are supplemented by thematic volumes on such topics as Remote Sensing and Geographical Information Systems in Epidemiology.

  • Advances in Microbial Physiology

    • 1 Edición
    • Volumen 47
    • Inglés
    The Editors of the Advances in Microbial Physiology series have always striven to provide a diverse range of top-quality papers on all aspects of microbial physiology. Coverage of 'holistic' topics or whole cell studies such as ion fluxes, stress responses and motility have gone hand-in-hand with detailed biochemical analyses of individual transport systems, electron transport pathways and many aspects of metabolism. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to publish topical and important reviews, interpreting physiology in its broadest context, to include all material that contributes to our understanding of how microorganisms and their component parts work.

  • Virus Structure

    • 1 Edición
    • Volumen 64
    • Inglés
    Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses.

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