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Elsevier

Libros en Ciencias de la Vida

  • Handbook of Proteolytic Enzymes

    Volume 4: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms
    • 4 Edición
    • Neil D. Rawlings
    • Inglés
    Handbook of Proteolytic Enzymes, Fourth Edition, Volume Four: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms includes over 250 chapters on known aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanisms. Chapters discuss each enzyme’s name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.Edited by world-renowned experts, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

  • Handbook of Proteolytic Enzymes

    Cysteine Peptidases
    • 4 Edición
    • Neil D. Rawlings
    • Inglés
    Handbook of Proteolytic Enzymes: Cysteine Peptidases, Fourth Edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. It includes over 300 chapters on known cysteine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of peptidases, extensive references, and links to PubMed and MEROPS databases.Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

  • Handbook of Proteolytic Enzymes

    Volume 5: Inhibitors of Proteolytic Enzymes
    • 4 Edición
    • Neil D. Rawlings
    • Inglés
    Handbook of Proteolytic Enzymes, Fourth Edition, Volume Five: Inhibitors of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. This volume offers a thorough discussion of known naturally-occurring and synthetic inhibitors of proteolytic enzymes. Each chapter includes enzyme inhibitor names, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of inhibitors, extensive references, and links to PubMed and MEROPS databases.Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

  • Handbook of Proteolytic Enzymes

    Serine and Threonine Peptidases
    • 4 Edición
    • Neil D. Rawlings
    • Inglés
    The Handbook of Proteolytic Enzymes, Fourth Edition is the latest release in this esteemed publication that stands as the most comprehensive work in applied enzymology and biocatalysis since the first edition published in 1998. Extensively updated, the new edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1 Edición
    • Anthony Chang + 1 más
    • Inglés
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.

  • Thiamine Pyrophosphate (TPP)-Dependent Enzymes

    • 1 Edición
    • Volumen 736
    • Inglés
    Methods in Enzymology: Thiamine pyrophosphate-depend... enzymes Thiamine pyrophosphate (TPP)-dependent enzymes are a diverse group of ubiquitous enzymes. They have in common the use of the biologically active form of vitamin B1 as a cofactor, which gives them the ability to catalyze the formation or cleavage of carbon-sulfur, carbon-oxygen, carbon-nitrogen, and especially carbon-carbon bonds. The specific characteristics of TPP-dependent enzymes, related to both the chemistry of thiamine pyrophosphate and their organization into multimeric subunits, have always aroused the interest of scientists. During these last years they developed original experimental approaches, and also new analytical tools to study, understand and modulate the activity of these enzymes. In the first section of this volume, we propose to address a wide range of methods related to TPP-dependent enzymes as target in health and agrochemistry. Then in a second section, we will focus more particularly on TPP-dependent enzymes in biocatalysis, and in particular on the associated techniques in the field of enzymatic engineering and repurposing. In a third section, we will then address an exciting topic, namely that of the assimilation of one-carbon compounds such as formaldehyde. We will see how TPP enzymes are a tool of choice in biotechnology to address this issue. Finally, we will focus on dual cofactor TPP-dependent enzymes and multi-enzyme complexes using structural and metabolic approaches.

  • Cell Death Part F

    • 1 Edición
    • Volumen 211
    • Inglés
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores the molecular mechanisms, regulatory pathways, and biological consequences of various forms of cell death—including apoptosis, necrosis, autophagy, and other non-canonical processes. Chapters in this new release include Flow cytometry analysis of mitochondrial apoptotic priming with BH3 profiling on senescent cells, Methods to study PIDDOsome and caspase 2 signaling, Isolation, characterization, and experimental applications of apoptotic bodies in vitro, Lipid ROS Measurement by Spectral Flow Cytometry based on the ratiometric dye BODIPYTM C11 581/591, and much more.Additional chapters cover CRISPR-Cas9 Screen to Identify Genes Regulating Cell Death, Flow cytometry-assisted discrimination of early apoptotic, late apoptotic and primary necrotic morphological markers in Saccharomyces cerevisiae, Cytofluorometric analysis of cell death in primary human neutrophils, Real-time tracking of cell death in human intestinal organoids: a quantitative imaging approach, and more.

  • The Metabolon

    • 1 Edición
    • Volumen 739
    • Inglés
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Biosimilars in Cancer

    • 1 Edición
    • Ranjita Shegokar + 1 más
    • Inglés
    Biosimilars in Cancer is a comprehensive resource addressing the role of biosimilars in treating various cancer types. This book offers a succinct yet thorough overview of current trends in oncology, covering 21 different cancers from liver to breast cancer. Each chapter provides detailed insights into the latest trends, fundamental facts, and practical and clinical data, making it an invaluable tool for academics and practitioners. By compiling this rich content into a single, accessible volume, the book empowers researchers and clinicians to enhance their understanding, and improve patient outcomes through the effective use of biosimilars in oncology. Targeted primarily at pharmaceutical researchers, biomedical scientists, and clinicians, Biosimilars in Cancer supports the growing oncology biosimilars market. It also provides critical insights for those involved in cancer diagnostics and clinical trials, helping them stay ahead in this rapidly progressing field.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1 Edición
    • Volumen 44
    • Inglés
    Advances in Biomembranes and Lipid Self-Assembly, Volume 44 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

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