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Elsevier

Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins

Insights into Pathogenic Mechanisms

  • 1 Edición - 1 de diciembre de 2026
  • Última edición
  • Autores: Parissa Farnia, Ali Akbar Velayati, Poopak Farnia, Jalaledin Ghanavi
  • Idioma: Inglés

Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms explores the structural and functional dynamics of nontub… Leer más

Descripción

Structural and Functional Dynamics of Nontuberculous Mycobacterium Proteins: Insights into Pathogenic Mechanisms explores the structural and functional dynamics of nontuberculous mycobacterium (NTM) proteins, focusing on their roles in pathogenicity, the mechanisms underlying microbial infections, and the potential for developing targeted therapeutic strategies to combat these emerging pathogens. The book begins with a foundational overview of nontuberculous mycobacteria (NTM), distinguishing them from Mycobacterium tuberculosis, their epidemiology, clinical significance, and structural biology. It discusses key structural features of NTM proteins and advanced techniques for protein structure determination, proteomic analyses, and bioinformatics approaches.

Additional sections investigate the pathogenic mechanisms and the complexities of the host-pathogen interaction. Concluding with insights into emerging research, interdisciplinary collaboration, future treatment, and prevention strategies, this book is a helpful resource for researchers and healthcare professionals engaged in the study of infectious diseases.

Puntos claves

  • Examines the structures of key proteins from nontuberculous mycobacteria, highlighting functional domains and binding sites essential for understanding how these bacteria cause disease
  • Analyzes interactions between nontuberculous mycobacteria and host cells to reveal the mechanisms of immune evasion and infection
  • Investigates potential therapeutic targets to help develop treatments to combat infections caused by nontuberculous mycobacteria
  • Addresses the growing challenge of antibiotic resistance by comparing mechanisms across slow and rapid-growing mycobacteria

De interès para

Researchers and clinical microbiologists specializing in infectious diseases, particularly those focused on nontuberculous mycobacteria (NTM) which includes those investigating the molecular and structural biology of mycobacterial pathogens, as well as those exploring their pathogenic mechanisms and antibiotic resistance profiles; healthcare professionals, such as infectious disease specialists and clinical microbiologists, who are involved in diagnosing and treating infections caused by NTM

Índice

1. Introduction to Nontuberculous Mycobacterium (NTM)

2. Key Structural Features of NTM Proteins

3. Pathogenic Mechanisms of Nontuberculous Mycobacteria

4. Virulence Factors of Nontuberculous Mycobacterium

5. Antibiotic Resistance in Nontuberculous Mycobacteria

6. Future Directions and Emerging Research in Nontuberculous Mycobacteria

7. Perspectives on the Future of Treatment and Prevention Strategies

Detalles del producto

  • Edición: 1
  • Última edición
  • Publicado: 1 de diciembre de 2026
  • Idioma: Inglés

Sobre los autores

PF

Parissa Farnia

Dr. Parissa Farnia is the Director of the Iranian National Reference Tuberculosis Laboratory (INRT) at the Mycobacteriology Research Center (MRC) in the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Her expertise and research interests include mycobacteriology, infectious diseases, and tuberculosis. She has published in multiple international journals such as Journal of Clinical Microbiology, Chest, Clinical infectious Diseases, and the International Journal of Tuberculosis and Lung Disease and serves on several editorial boards including International Journal of Mycobacteriology, the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, and the Biomedical and Biotechnology Research Journal.
Afiliaciones y experiencia
Director, Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), WHO Collaborating Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

AV

Ali Akbar Velayati

Dr. Ali Akbar Velayati is the Director of the National Research Institute of Tuberculosis and Lung Diseases (NRITLD) at the Shahid Beheshti University of Medical Sciences. He is a Full Professor of Pediatric Infectious Diseases, and he has guided more than 300 MD and PhD students. He is also the Head of Mycobacteriology Research Center (MRC) in NRITLD, where he directly monitors the basic and clinical trial on tuberculosis. Dr. Velayati is the President of the Asian African Society of Mycobacteriology and of the Society of Biomedical and Biotechnology Scientists. He is the Chief Editor of the International Journal of Mycobacteriology, the Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, and the Biomedical and Biotechnology Research Journal.
Afiliaciones y experiencia
Director, National Research Institute of Tuberculosis and Lung Disease (NRITLD), WHO Collaborating Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran

PF

Poopak Farnia

Poopak Farnia is currently an Associate Professor in the Biotechnology, Tissue Engineering and Stem Cells Unit of the Mycobacteriology Research Center at the National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences in Tehran, Iran.
Afiliaciones y experiencia
Associate Professor in Biotechnology, Tissue Engineering and Stem Cells Unit, Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran

JG

Jalaledin Ghanavi

Jalaledin Ghanavi, MD, is surgeon, an Associate Professor, and the Head of the Department of Tissue Engineering and Experimental Medicine in the Mycobacteriology Research Center at the National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences in Tehran, Iran. He received the MD degree from the Isfahan University of Medical Science and has medical expertise in general medicine and general surgery. His ongoing research interests include tissue engineering, nanoarchitectonics, biomedicine, and nanomedicine, and he holds five U.S patents.

Afiliaciones y experiencia
Associate Professor and the Head of the Department of Tissue Engineering and Experimental Medicine, Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran