Progress in Medicinal Chemistry

Chapter One: Enabling Chemistry Technologies and Parallel Synthesis—Accelerators of Drug Discovery Programmes

• Abstract
• 1 Introduction
• 2 The Evolution of Flow-Based Approaches to Synthesis
• 3 Use of High-Temperature Chemistries
• 4 Use of Photochemical and Electrochemical Reactions
• 5 Use of Hazardous Gases (e.g. Diazomethane) in Flow
• 6 Library Design Tools and Processes
• 7 Use of Flow Chemistry for Library Synthesis
• 8 Summary and Future Perspectives
• Acknowledgements

Chapter Two: Development of LRRK2 Inhibitors for the Treatment of Parkinson's Disease

• Abstract
• 1 Introduction
• 2 LRRK2 Biology
• 3 Structural Biology of LRRK2
• 4 Overview of Selective Inhibitors of LRRK2
• 5 Conclusion

Chapter Three: Recent Progress in the Discovery and Development of TRPA1 Modulators

• Abstract
• 1 TRPA1: An Introduction
• 2 Validation as a Target for Drug Discovery
• 3 Medicinal Chemistry and Clinical Status of TRPA1 Modulators
• 4 Recent Structural Insights
• 5 Conclusions and Outlook

Chapter Four: Small Molecule Inhibition of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4)

• Abstract
• 1 Introduction
• 2 Small Molecule IRAK4 Inhibitor Discovery
• 3 Summary of Clinical Status
• 4 Conclusion