Integrative Omics in Parkinson's Disease
- 1 Edición - 19 de septiembre de 2024
- Última edición
- Editor: Joanne Trinh
- Idioma: Inglés
Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's… Leer más
Descripción
Descripción
Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinson's disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinson's disease.
Puntos claves
Puntos claves
- Reviews evolution of omics technologies from the first identification of monogenic forms of Parkinson’s disease
- Outlines machine learning algorithm application to Parkinson’s disease datasets
- Reviews big datasets on gene-environment interactions, genomics, epigenetics, and transcriptomics
- Identifies how the microbiome influences Parkinson’s disease in mouse models and patients
- Provides outlook for therapies with induced-pluripotent stem cell models
De interès para
De interès para
Índice
Índice
2. Monogenic and Complex genetics PD
3. Genetic risk scores
4. Mendelian Randomization
5. Methods to investigate somatic structural variants in synucleinopathies
6. Mitochondrial genetics
7. Epigenetics in PD genes
8. The microbiome
9. Genetic modifiers in reduced penetrance: X-linked dystonia
10. Long-read transcriptomics in neurodegeneration
11. Gene-environment interactions and behaviour
12. Introduction to prediction modeling using machine learning and omics data
13. IPSCs and OMICs merging
Detalles del producto
Detalles del producto
- Edición: 1
- Última edición
- Publicado: 24 de septiembre de 2024
- Idioma: Inglés
Sobre el editor
Sobre el editor
JT
Joanne Trinh
Joanne Trinh, Ph.D., is a Heisenberg professor at the Institute of Neurogenetics, University of Lübeck. Dr. Joanne Trinh received her doctorate in medical genetics at the University of British Columbia. She subsequently joined the Institute of Neurogenetics in Lübeck, where she obtained a faculty position. She is now head of the “Integrative Omics in Parkinson’s Disease” research group, which investigates the role of mosaic variants, nuclear and mitochondrial genome sequences, and lifestyle and environmental factors in parkinsonism. She is on the editorial board of Annals of Neurology and an associate editor of Frontiers in Neurology. Her research group in Lübeck will continue to use big-data approaches to elucidate the causes of neurological disease.